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Cellular Sensors of Famine/Feast: A Final Word

Progress:

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We take advantage of 2 strategies in The Blueprint (Feast and Famine) that result in a combustion engine-like effect on your metabolism.

Following then, is a peak into some research studies detailing just what guages your cells use to make the complex metabolic adjustments The Blueprint creates:

1.Ruderman NB, et al. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999;276:E1–E18. [PubMed]

2.Marshall S, Bacote V, Traxinger RR. Complete inhibition of glucose-induced desensitization of the glucose transport system by inhibitors of mRNA synthesis. Evidence for rapid turnover of glutamine:fructose-6-phosphate amidotransferase. J Biol Chem. 1991;266:10155–10161. [PubMed]

3.Obici S, et al. Identification of a biochemical link between energy intake and energy expenditure. J Clin Invest. 2002;109:1599–1605. doi:10.1172/JCI200215258. [PubMed]

4.Bouchard C, et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477–1482. [PubMed]

Take away: By rotating each time-sensitive dietary phase shift, The Blueprint keeps you way ahead of your body and progress ongoing.