Cyclic GMP (cGMP) Activation
The Blueprint takes advantage of a very over-looked property of Ecdysterone, it’s ability to activate a very rapid state of cyclic GMP.
Briefly, cAMP is associated with muscle loss. If you’ve been following along you’ll note this is reflective of the Famine/Feast phases respectively.
I was aware of cAMP/cGMP for some time but hadn’t put the full picture together until reading the following book while toying with “The Warrior Diet”. His companion book (below) is a superb read and should be on your bookshelf.
“Maximum Muscle, Minimum Fat: The Science of Physical Perfection” by Ori Hofmekler. Ori is also the author of the Warrior Diet.
You can order the book here: http://www.amazon.com/Maximum-Muscle-Minimum-Ori-Hofmekler/dp/0938045520
There was one chapter in particular that was instrumental in my formulating of The Blueprint: Chapter 2 focusing on:
The Combustion Engine Principle 19
Under and over-feeding modulate cyclic AMP (cAMP) and cyclic GMP (cGMP) respectively. Cyclic GMP (cGMP) is associated with muscle growth. Turns out switching back and forth (from famine to feast) potentiates the effect of both.
Now, here’s something else almost everyone has overlooked: Ecdysterone is a known amplifier of cGMP and it decreases cAMP shortly after administration.
“A rapid increase of cGMP and a decrease of cAMP levels in mouse plasma, together with a decrease of PKA activity in liver were described 40 min after an intraperitoneal injection of 10 μg 20E (Catalán et al., 1979a&b, 1982).” 20E as referenced is 20-hydroxyecdysterone, found in Mass Pro Synthagen or Progenadrex.
This clue was buried deep in LaFont’s excellent paper, Practical uses for ecdysteroids in mammals including humans: an update R. Lafont1,3 and L. Dinan2,4. See page 16 of 30, under sub-heading: Rapid membrane effects
Accordingly, your dosing of ecdysterone is positioned in the Feast (not the Famine) phase where it would work against the cAMP state we’re trying to create. I’m going to put a finer point on that now and recommend that you ingest Synthagen or Progenadrex prior to your workouts due to the cGMP info cited here. By the time your workout is finished, your system should be swimming in cGMP.
You can see now why I recommend Synthagen and Progenadrex (Ecdy being the center piece ingredient) be used during select phases of The Blueprint and in combination with other variables to maximize its impact.