Truth about 2,4-Dinitrophenol (DNP)


I’ve got a question about 2,4-Dinitrophenol (DNP). Is it really that dangerous? Because I’ve been reading in several places where it’s not and I know you’ll give me the straight dirt.


The straight dirt is that DNP isn’t as dangerous as you’ve been led to believe – it’s even more dangerous. There are a couple of reasons for this, not the least of which is the crap you’ve been reading about it. I’ve read these same articles and it lulls the reader into a false sense of security IMO. More importantly, there are lies being told about it. Like there are ways to do safe cycles frequently. Let me be very clear, these lies are potentially deadly.

Drawing from another example, you no doubt recall the space shuttle Challenger blowing up in 1986. For years, the narrative NASA spun was that the 7 astronauts died instantly in the explosion. The fact is they were alive for the 2 minutes and 45 seconds it took for the crew capsule to fall and slam into the ocean.

They didn’t die instantly. That was ostensibly a lie NASA told, to protect the astronauts families. The truth was only learned from a FOIA or Freedom of Information Act request by the press. More importantly because of that lie, critical lessons weren’t learned and as a result, Columbia’s astronauts burned up during re-entry 17 years later. A fitting example, given we’re discussing DNP.

2,4-Dinitrophenol (DNP)

The compound is what’s known as a mitochondrial uncoupler. It causes weight loss by making cellular respiration less efficient. It goes like this: When your body oxidizes sugar, fat, or proteins energy is produced. Your body is designed to use that energy to make ATP.

DNP does something different – it turns that energy into heat. But here’s the rub: The effective dose for weight loss and the dose that kills 50% of lab animals (the LD50) is virtually the same. Worse, some of these articles advocate front loading the drug – which is virtually a one way ticket to the morgue.

Death by DNP

And understand this: Death by DNP is agonizing. It’s like microwaving yourself – you cook, from the inside out. In the event you make it to the emergency room, there’s little they can do for you – there is no known antidote to DNP, other than immersing you in ice water and shooting said ice water up your rectum.

And it almost never works – death is all but assured by the time most users realize they’re in trouble. So if ice water enemas while in agony sound like a good time, I suppose you’ll thoroughly enjoy the DNP experience.

My Reference Point

In years past, I experimented with Usnic Acid – sold as a supplement at the time and included in several of Syntrax’s offerings (Lipokinetix, if I’m not mistaken). It’s what could be considered as a kinder, gentler cousin of DNP. I distinctly recall using it during the dead of winter in new England, laying in bed at night completely naked with the window wide open and snow coming through it. Even with all that, I was still sweating up a storm.

DNP is like Usnic Acid on steroids, so I can only imagine the hell some users went through. Reportedly, it wasn’t uncommon to sweat yellow, be incredibly weak due to the ATP depletion and it felt like wearing a 100lb weight vest just walking around – no energy whatsoever.

Add to this the distinct possibility of dying and yes – DNP is as dangerous a gamble as one can take. I can think of only insulin as a more dangerous bodybuilding drug, and at least there you would slip into a diabetic coma before dying, unaware of the damage you’ve done. Not everyone is so lucky though. I believe Carl has a friend who is still lying in a hospital bed, largely unresponsive.


With DNP, you’re going to suffer and I mean greatly. It’s just not worth it man, not even close. Take a few more weeks to diet, look into other effective fat burners like E/C, Tagamet (cimetidine hcl), even clenbuterol would be preferable to this stuff IMO.

So there it is brother, the straight dirt on DNP. Trust me on this one – its just not worth it…

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Coach Rob Regish

Rob Regish is an internationally recognized name in the field of health and fitness. He's been a weekly contributor to for almost a decade, answering listener questions from around the world.

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